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Article

The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster.

The Journal of biological chemistry - 29 Aug 2003

Bauer Holger, Massey Vincent, Arscott L David, Schirmer R Heiner, Ballou David P, Williams Charles H

Abstract excerpt

Drosophila melanogaster thioredoxin reductase-1 (DmTrxR-1) is a key flavoenzyme in dipteran insects, where it substitutes for glutathione reductase. DmTrxR-1 belongs to the family of dimeric, high Mr thioredoxin reductases, which catalyze reduction of thioredoxin by NADPH. Thioredoxin reductase has an N-terminal redox-active disulfide (Cys57-Cys62) adjacent to the flavin and a redox-active C-terminal cysteine...

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PMID: 12816954
DOI: 10.1074/jbc.M303762200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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