Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.

The Journal of biological chemistry - 30 Jul 2004

Inácio Angela, Silva Ana Luísa, Pinto Joana, Ji Xinjun, Morgado Ana, Almeida Fátima, Faustino Paula, Lavinha João, Liebhaber Stephen A, Romão Luísa

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs containing premature translation termination codons. In mammalian cells, a termination codon is ordinarily recognized as "premature" if it is located greater than 50-54 nucleotides 5' to the final exon-exon junction. We have described a set of naturally occurring human beta-globin gene mutations that apparently contradict this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Initiator
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Codon, Terminator

Share to Globins

Share to Oligonucleotides

Share to Polyribosomes

Share to Ribonucleases

Share to Sucrose

Source

Identifiers

PMID: 15161914
DOI: 10.1074/jbc.M405024200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.PMID 15161914Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs.Semantic proximity Read ↗

Abnormally spliced β-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decaySemantic proximity Read ↗

The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay.Semantic proximity Read ↗

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.Semantic proximity Read ↗

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decaySemantic proximity Read ↗

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.Semantic proximity Read ↗

Lost in Translation: Ribosome-Associated mRNA and Protein Quality ControlsSemantic proximity Read ↗

The meaning of nonsense.Semantic proximity Read ↗

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and DiseaseSemantic proximity Read ↗

Nonsense-mediated mRNA decayin health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.