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Article

A novel method for estimating substitution rate variation among sites in a large dataset of homologous DNA sequences.

Genetics - 1 Feb 2001

Pesole G, Saccone C

Abstract excerpt

We present here a novel method to estimate the site-specific relative variability in large sets of homologous sequences. It is based on the simple idea that the more closely related are the compared sequences, the higher the probability of observing nucleotide changes at rapidly evolving sites. A simulation study has been carried out to support the reliability of the method, which has been applied also to...

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Identifiers

PMID: 11157002
DOI: 10.1093/genetics/157.2.859
PMCID: PMC1461530

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Source receipt: pubmed, retrieved 7 Sept 2026.

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