A high observed substitution rate in the human mitochondrial DNA control region.

doi:10.1038/ng0497-363

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Article

A high observed substitution rate in the human mitochondrial DNA control region.

Nature genetics - 1 Apr 1997

Parsons T J, Muniec D S, Sullivan K, Woodyatt N, Alliston-Greiner R, Wilson M R, Berry D L, Holland K A, Weedn V W, Gill P, Holland M M

Abstract excerpt

The rate and pattern of sequence substitutions in the mitochondrial DNA (mtDNA) control region (CR) is of central importance to studies of human evolution and to forensic identity testing. Here, we report a direct measurement of the intergenerational substitution rate in the human CR. We compared DNA sequences of two CR hypervariable segments from close maternal relatives, from 134 independent mtDNA lineages...

Topics

Animals
Base Sequence
Child
DNA, Mitochondrial
Female
Genetic Variation
Hominidae
Humans
Male
Mutagenesis
Pedigree
Sequence Analysis, DNA

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Open in PubMed

Identifiers

PMID: 9090380
DOI: 10.1038/ng0497-363

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