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Article

Evolution of Local Mutation Rate and Its Determinants.

Molecular biology and evolution - 1 May 2017

Terekhanova Nadezhda V, Seplyarskiy Vladimir B, Soldatov Ruslan A, Bazykin Georgii A

Abstract excerpt

Mutation rate varies along the human genome, and part of this variation is explainable by measurable local properties of the DNA molecule. Moreover, mutation rates differ between orthologous genomic regions of different species, but the drivers of this change are unclear. Here, we use data on human divergence from chimpanzee, human rare polymorphism, and human de novo mutations to predict the substitution rate at...

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Identifiers

PMID: 28138076
DOI: 10.1093/molbev/msx060
PMCID: PMC5850301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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