Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA.

doi:10.1007/BF00182747

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Article

Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA.

Journal of molecular evolution - 1 Dec 1993

Wakeley J

Abstract excerpt

More than an order of magnitude difference in substitution rate exists among sites within hypervariable region 1 of the control region of human mitochondrial DNA. A two-rate Poisson mixture and a negative binomial distribution are used to describe the distribution of the inferred number of change...

Topics

Biological Evolution
DNA, Mitochondrial
Genetic Variation
Humans
Models, Genetic
Mutation

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