Pattern of nucleotide substitution and rate heterogeneity in the hypervariable regions I and II of human mtDNA.

doi:10.1093/genetics/152.3.1103

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Article

Pattern of nucleotide substitution and rate heterogeneity in the hypervariable regions I and II of human mtDNA.

Genetics - 1 Jul 1999

Meyer S, Weiss G, von Haeseler A

Abstract excerpt

This study provides a comprehensive survey of the complex pattern of nucleotide substitution in the control region of human mtDNA, which is of central importance to the studies of human evolution. A total of 1229 different hypervariable region I (HVRI) and 385 different hypervariable region II (HVRII) sequences were analyzed using a complex substitution model. Moreover, we suggest a new method to assign relative...

Topics

DNA, Mitochondrial
Databases, Factual
Evolution, Molecular
Genetic Variation
Humans
Models, Genetic
Models, Statistical

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Identifiers

PMID: 10388828
DOI: 10.1093/genetics/152.3.1103
PMCID: PMC1460673

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