Article
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase.
Science (New York, N.Y.) - 1 Dec 1995
Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H, Metzger D, Chambon P
Abstract excerpt
The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1). This Ser118 is phosphorylated by mitogen-activated protein kinase (MAPK) in vitro and in cells treated with epidermal growth factor (EGF) and insulin-like growth factor (IGF) in vivo. Overexpression of MAPK kinase (MAPKK) or of the guanine nucleotide binding...
Topics
- Amino Acid Sequence
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Enzyme Activation
- Epidermal Growth Factor
- Estradiol
- Estrogen Antagonists
- Humans
- Mitogen-Activated Protein Kinase Kinases