Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined activities of hedgehog signaling inhibitors regulate pancreas development.

Development (Cambridge, England) - 1 Oct 2003

Kawahira Hiroshi, Ma Nancy H, Tzanakakis Emmanouhl S, McMahon Andrew P, Chuang Pao-Tien, Hebrok Matthias

Abstract excerpt

Hedgehog signaling is known to regulate tissue morphogenesis and cell differentiation in a dose-dependent manner. Loss of Indian hedgehog (Ihh) results in reduction in pancreas size, indicating a requirement for hedgehog signaling during pancreas development. By contrast, ectopic expression of sonic hedgehog (Shh) inhibits pancreatic marker expression and results in transformation of pancreatic mesenchyme into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor 10
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Lectins, C-Type

Share to Pancreas

Share to Pancreatitis-Associated Proteins

Share to Patched-1 Receptor

Share to Patched Receptors

Source

Identifiers

PMID: 12917290
DOI: 10.1242/dev.00653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined activities of hedgehog signaling inhibitors regulate pancreas development.PMID 12917290Read ↗

Regulation of pancreas development by hedgehog signaling.Semantic proximity Read ↗

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tractSemantic proximity Read ↗

Sonic hedgehog is required early in pancreatic islet development.Semantic proximity Read ↗

Hedgehog signaling in pancreas development and disease.Semantic proximity Read ↗

Hedgehog signals regulate multiple aspects of gastrointestinal developmentSemantic proximity Read ↗

Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal TractSemantic proximity Read ↗

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas.Semantic proximity Read ↗

Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.Semantic proximity Read ↗

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.Semantic proximity Read ↗

Hedgehog Signaling in Gastrointestinal Development and DiseaseSemantic proximity Read ↗

Hedgehog/Ras interactions regulate early stages of pancreatic cancer.Semantic proximity Read ↗

Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.