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Article

Specific interaction between anticodon nuclease and the tRNA(Lys) wobble base.

Journal of molecular biology - 19 Jan 2001

Jiang Y, Meidler R, Amitsur M, Kaufmann G

Abstract excerpt

The bacterial tRNA(Lys)-specific PrrC-anticodon nuclease cleaves its natural substrate 5' to the wobble base, yielding 2',3'-cyclic phosphate termini. Previous work has implicated the anticodon of tRNA(Lys) as a specificity element and a cluster of amino acid residues at the carboxy-proximal half of PrrC in its recognition. We further examined these assumptions by assaying unmodified and hypomodified derivatives...

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Share to RNA, Bacterial

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Source

Identifiers

PMID: 11152597
DOI: 10.1006/jmbi.2000.4282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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