Article
Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations.
eLife - 2 Jun 2023
van den Berg Daan F, van der Steen Baltus A, Costa Ana Rita, Brouns Stan J J
Abstract excerpt
Transfer RNAs (tRNAs) in bacteriophage genomes are widespread across bacterial host genera, but their exact function has remained unclear for more than 50 years. Several hypotheses have been proposed, and the most widely accepted one is codon compensation, which suggests that phages encode tRNAs that supplement codons that are less frequently used by the host. Here, we combine several observations and propose a...
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