Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases.

Article

Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases.

The EMBO journal - 1 Mar 1996

Auld D S, Schmimmel P

Abstract excerpt

The specific aminoacylation of RNA oligonucleotides whose sequences are based on the acceptor stems of tRNAs can be viewed as an operational RNA code for amino acids that may be related to the development of the genetic code. Many synthetases also have direct interactions with tRNA anticodon trip...

Topics

Amino Acid Sequence
Anticodon
Base Sequence
Binding Sites
DNA, Bacterial
Enzyme Stability
Escherichia coli
Genetic Variation
Helix-Loop-Helix Motifs
Isoleucine-tRNA Ligase
Methionine-tRNA Ligase
Molecular Sequence Data
Mutagenesis, Insertional

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