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Article

PrrC-anticodon nuclease: functional organization of a prototypical bacterial restriction RNase.

Nucleic acids research - 1 Jan 2006

Blanga-Kanfi Shani, Amitsur Michal, Azem Abdussalam, Kaufmann Gabriel

Abstract excerpt

The tRNA(Lys) anticodon nuclease PrrC is associated in latent form with the type Ic DNA restriction endonuclease EcoprrI and activated by a phage T4-encoded inhibitor of EcoprrI. The activation also requires the hydrolysis of GTP and presence of dTTP and is inhibited by ATP. The N-proximal NTPase domain of PrrC has been implicated in relaying the activating signal to a C-proximal anticodon nuclease site by...

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PMID: 16790566
DOI: 10.1093/nar/gkl415
PMCID: PMC1484252

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