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Article

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.

Journal of cell science - 1 Jun 1997

Jackson D, Bresnick J, Rosewell I, Crafton T, Poulsom R, Stamp G, Dickson C

Abstract excerpt

We have used the mouse mammary tumor virus promoter to express two dominant negative (DN) fibroblast growth factor receptor (FGFR) isoforms in the mammary epithelium of transgenic mice. While expression of DN-FGFR1(IIIc) showed no discernible phenotype, a similar kinase negative form of FGFR2(IIIb) caused a marked impairment of lobuloalveolar development. The growth retardation was apparent by mid-pregnancy and...

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Share to Gene Expression
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9202386
DOI: 10.1242/jcs.110.11.1261

Genes

FGFR1
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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