Article
Impaired thrombin generation in beta 2-glycoprotein I null mice.
The Journal of biological chemistry - 27 Apr 2001
Sheng Y, Reddel S W, Herzog H, Wang Y X, Brighton T, France M P, Robertson S A, Krilis S A
Abstract excerpt
Autoimmune antibodies to beta(2)-glycoprotein I (beta2GPI) have been proposed to be clinically relevant because of their strong association with thrombosis, miscarriage, and thrombocytopenia. By using a homologous recombination approach, beta2GPI-null mice were generated to begin to understand the physiologic and pathologic role of this prominent plasma protein in mammals. When beta2GPI heterozygotes on a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.