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Article

Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols.

British journal of pharmacology - 1 Dec 2000

Lerche C, Seebohm G, Wagner C I, Scherer C R, Dehmelt L, Abitbol I, Gerlach U, Brendel J, Attali B, Busch A E

Abstract excerpt

Slowly activating I:(Ks) (KCNQ1/MinK) channels were expressed in Xenopous: oocytes and their sensitivity to chromanols was compared to homomeric KCNQ1 channels. To elucidate the contribution of the ss-subunit MinK on chromanol block, a formerly described chromanol HMR 1556 and its enantiomer S5557 were tested for enantio-specificity in blocking I:(Ks) and KCNQ1 as shown for the single enantiomers of chromanol...

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Source

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Identifiers

PMID: 11139424
DOI: 10.1038/sj.bjp.0703734
PMCID: PMC1572493

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols.PMID 11139424Read ↗

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