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Article

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization.

European journal of medicinal chemistry - 1 Aug 2011

Sintra Grilo Liliana, Carrupt Pierre-Alain, Abriel Hugues, Daina Antoine

Abstract excerpt

The hERG voltage-gated potassium channel mediates the cardiac I(Kr) current, which is crucial for the duration of the cardiac action potential. Undesired block of the channel by certain drugs may prolong the QT interval and increase the risk of malignant ventricular arrhythmias. Although the molecular determinants of hERG block have been intensively studied, not much is known about its stereoselectivity....

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Source

Identifiers

PMID: 21624711
DOI: 10.1016/j.ejmech.2011.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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