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Article

The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.

The Journal of general physiology - 1 Feb 2007

Panaghie Gianina, Abbott Geoffrey W

Abstract excerpt

Voltage-gated potassium (Kv) channels extend their functional repertoire by coassembling with MinK-related peptides (MiRPs). MinK slows the activation of channels formed with KCNQ1 alpha subunits to generate the voltage-dependent I(Ks) channel in human heart; MiRP1 and MiRP2 remove the voltage dependence of KCNQ1 to generate potassium "leak" currents in gastrointestinal epithelia. Other Kv alpha subunits interact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17227916
DOI: 10.1085/jgp.200609612
PMCID: PMC2154355

Genes

KCNQ1
KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.PMID 17227916Read ↗

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