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Article

Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex.

Neuron - 25 Sept 2003

Chen Haijun, Kim Leo A, Rajan Sindhu, Xu Shuhua, Goldstein Steve A N

Abstract excerpt

I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybdotoxin (CTX)-sensitive subunit variants are applied. First, CTX on rate, off rate, and...

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Source

Identifiers

PMID: 14527430
DOI: 10.1016/s0896-6273(03)00570-1

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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