A toxin to nervous, cardiac, and endocrine ERG K + channels isolated from Centruroides noxius scorpion venom

Abstract excerpt

ABSTRACT Toxins isolated from a variety of venoms are tools for probing the physiological function and structure of ion channels. The ether‐a‐go‐go ‐related genes ( erg ) codify for the K + channels (ERG), which are crucial in neurons and are impaired in human long‐QT syndrome and Drosophila ‘seizure’ mutants. We have isolated a peptide from the scorpion Centruroides noxius Hoffmann that has no sequence...

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