Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system.

Molecular pharmacology - 1 May 2006

Restano-Cassulini Rita, Korolkova Yuliya V, Diochot Sylvie, Gurrola Georgina, Guasti Leonardo, Possani Lourival D, Lazdunski Michel, Grishin Eugene V, Arcangeli Annarosa, Wanke Enzo

Abstract excerpt

The ether-à-go-go-related gene (erg) K+ channels are known to be crucial for life in Caenorhabditis elegans (mating), Drosophila melanogaster (seizure), and humans (LQT syndrome). The erg genes known to date (erg1, erg2, and erg3) are highly expressed in various areas of the rat and mouse central nervous system (CNS), and ERG channel blockers alter firing accommodation. To assign physiological roles to each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Patch-Clamp Techniques
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Central Nervous System

Share to CHO Cells

Share to Ether-A-Go-Go Potassium Channels

Share to Long QT Syndrome

Share to Membrane Potentials

Source

Identifiers

PMID: 16497878
DOI: 10.1124/mol.105.019729

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system.PMID 16497878Read ↗

A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.Semantic proximity Read ↗

The eag family of K+ channels in Drosophila and mammals.Semantic proximity Read ↗

An ERG channel inhibitor from the scorpion Buthus eupeus.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.Semantic proximity Read ↗

A toxin to nervous, cardiac, and endocrine ERG K + channels isolated from Centruroides noxius scorpion venomSemantic proximity Read ↗

Functional Analysis of a Mouse Brain Elk-Type K+ChannelSemantic proximity Read ↗

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.Semantic proximity Read ↗

Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans.Semantic proximity Read ↗

Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.Semantic proximity Read ↗

Erabutoxin mutants demonstrate interface selectivity at human fetal and adult muscle-type nicotinic acetylcholine receptors.Semantic proximity Read ↗

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System.Semantic proximity Read ↗

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.