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Article

Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas.

The Journal of investigative dermatology - 1 Mar 2009

Steinmann Katharina, Kluwe Lan, Friedrich Reinhard E, Mautner Victor-Felix, Cooper David N, Kehrer-Sawatzki Hildegard

Abstract excerpt

Plexiform neurofibromas constitute a serious burden for patients with neurofibromatosis type 1 (NF1), a common autosomal dominant disorder characterized by pigmentary changes and tumorous skin lesions (neurofibromas). Despite the prominence of these benign tumors in NF1 patients, the mechanisms underlying the tumor-associated loss of heterozygosity (LOH) in plexiform neurofibromas have not been extensively...

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Share to Chromosomes, Human, Pair 17
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Neurofibromatosis 1

Share to Loss of Heterozygosity

Share to Neurofibromatosis 1

Share to Oligonucleotide Probes

Share to Recombination, Genetic

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Source

Identifiers

PMID: 18800150
DOI: 10.1038/jid.2008.274

Genes

SUZ12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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