Article
Antifibrotic action of Cu/Zn SOD is mediated by TGF-beta1 repression and phenotypic reversion of myofibroblasts.
Free radical biology & medicine - 1 Jan 2001
Vozenin-Brotons M C, Sivan V, Gault N, Renard C, Geffrotin C, Delanian S, Lefaix J L, Martin M
Abstract excerpt
Skin fibrosis is characterized by the proliferation and accumulation of activated fibroblasts called myofibroblasts. They exhibit specific cytoskeletal differentiation, overexpress the fibrogenic cytokine TGF-beta1, synthesize excess extracellular matrix compounds and exhibit a depleted antioxidant metabolism. Recently, SOD was successfully used as an antifibrotic agent in vivo, thus challenging the postulate of...
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