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Article

Cu/Zn superoxide dismutase modulates phenotypic changes in cultured fibroblasts from human skin with chronic radiotherapy damage.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Mar 2001

Delanian S, Martin M, Bravard A, Luccioni C, Lefaix J L

Abstract excerpt

PURPOSE: As we previously observed that bovine liposomal Cu/Zn SOD (LipSOD) reduces cutaneous radiation-induced fibrosis (RIF) in human therapeutic assays the mechanisms involved were investigated here by an in vitro study of the LipSOD effects on cellular antioxidant metabolism and regulation of matrix degradation. METHODS: Primary cultures of human fibroblasts harvested from normal or RIF skin were treated with...

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PMID: 11230895
DOI: 10.1016/s0167-8140(00)00332-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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