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Article

Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis.

Biomolecules - 23 Jul 2021

Tai Yifan, Woods Emma L, Dally Jordanna, Kong Deling, Steadman Robert, Moseley Ryan, Midgley Adam C

Abstract excerpt

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments. However, due to shared cellular markers with several other phenotypes, the specific targeting...

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Identifiers

PMID: 34439762
DOI: 10.3390/biom11081095
PMCID: PMC8391320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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