Article
Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2001
Wu G, Xie X, Lu Z H, Ledeen R W
Abstract excerpt
Mice engineered to lack GM2/GD2 synthase (GalNAc-T), with resultant deficit of GM2, GD2, and all gangliotetraose gangliosides, were originally described as showing a relatively normal phenotype with only a slight reduction in nerve conduction. However, a subsequent study showed that similar animals suffer axonal degeneration, myelination defects, and impaired motor coordination. We have examined the behavior of...
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