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Article

Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor.

Blood - 1 Jan 2001

Ciric B, VanKeulen V, Rodriguez M, Kyle R A, Gertz M A, Pease L R

Abstract excerpt

The course of clonal evolution of 2 related clones in the blood of a patient with Waldenstrom macroglobulinemia (WM) indicates the functional importance for the expression of the B-cell receptor for the survival of these malignant cells. Protein and nucleotide sequencing of the paraproteins' variable regions revealed 2 predominant Vlambda and 2 VH sequences, each set comprised in the ratio 1:1.5. The 2 VH...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11133777
DOI: 10.1182/blood.v97.1.321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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