Article
Clonotypic analysis of immunoglobulin heavy chain sequences in patients with Waldenström's macroglobulinemia: correlation with MYD88 L265P somatic mutation status, clinical features, and outcome.
BioMed research international - 1 Jan 2014
Petrikkos Loizos, Kyrtsonis Marie-Christine, Roumelioti Maria, Georgiou George, Efthymiou Anna, Tzenou Tatiana, Panayiotidis Panayiotis
Abstract excerpt
We performed IGH clonotypic sequence analysis in WM in order to determine whether a preferential IGH gene rearrangement was observed and to assess IGHV mutational status in blood and/or bone marrow samples from 36 WM patients. In addition we investigated the presence of MYD88 L265P somatic mutation. After IGH VDJ locus amplification, monoclonal VDJ rearranged fragments were sequenced and analyzed. MYD88 L265P...
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