The cellular origin and malignant transformation of Waldenström macroglobulinemia.

doi:10.1182/blood-2014-09-602565

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Article

The cellular origin and malignant transformation of Waldenström macroglobulinemia.

Blood - 9 Apr 2015

Paiva Bruno, Corchete Luis A, Vidriales Maria-Belen, García-Sanz Ramón, Perez Jose J, Aires-Mejia Irene, Sanchez Maria-Luz, Barcena Paloma, Alignani Diego, Jimenez Cristina, Sarasquete Maria-Eugenia, Mateos María-Victoria, Ocio Enrique M, Puig Noemi, Escalante Fernando, Hernández José, Cuello Rebeca, García de Coca Alfonso, Sierra Magdalena, Montes Maria-Carmen, González-López Tomás J, Galende Josefina, Bárez Abelardo, Alonso José, Pardal Emilia, Orfao Alberto, Gutierrez Norma C, San Miguel Jesús F

Abstract excerpt

Although information about the molecular pathogenesis of Waldenström macroglobulinemia (WM) has significantly advanced, the precise cell of origin and the mechanisms behind WM transformation from immunoglobulin-M (IgM) monoclonal gammopathy of undetermined significance (MGUS) remain undetermined. Here, we undertook an integrative phenotypic, molecular, and genomic approach to study clonal B cells from newly...

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PMID: 25655603
DOI: 10.1182/blood-2014-09-602565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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