Article
Clonal architecture and evolutionary history of Waldenström's macroglobulinemia at the single-cell level.
Disease models & mechanisms - 1 Aug 2023
García-Sanz Ramón, García-Álvarez María, Medina Alejandro, Askari Elham, González-Calle Verónica, Casanova María, de la Torre-Loizaga Igor, Escalante-Barrigón Fernando, Bastos-Boente Miguel, Bárez Abelardo, Vidaña-Bedera Nerea, Alonso José María, Sarasquete María Eugenia, González Marcos, Chillón María Carmen, Alcoceba Miguel, Jiménez Cristina
Abstract excerpt
To provide insight into the subclonal architecture and co-dependency patterns of the alterations in Waldenström's macroglobulinemia (WM), we performed single-cell mutational and protein profiling of eight patients. A custom panel was designed to screen for mutations and copy number alterations at the single-cell level in samples taken from patients at diagnosis (n=5) or at disease progression (n=3). Results...
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