Article
Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute - Waldenström Macroglobulinemia 1.
Leukemia & lymphoma - 1 Feb 2013
Chitta Kasyapa S, Paulus Aneel, Ailawadhi Sikander, Foster Barbara A, Moser Michael T, Starostik Petr, Masood Aisha, Sher Taimur, Miller Kena C, Iancu Dan M, Conroy Jeffrey, Nowak Norma J, Sait Sheila N, Personett David A, Coleman Morton, Furman Richard R, Martin Peter, Ansell Stephen M, Lee Kelvin, Chanan-Khan Asher A
Abstract excerpt
Understanding the biology of Waldenström macroglobulinemia is hindered by a lack of preclinical models. We report a novel cell line, RPCI-WM1, from a patient treated for WM. The cell line secretes human immunoglobulin M (h-IgM) with κ-light chain restriction identical to the primary tumor. The cell line has a modal chromosomal number of 46 and harbors chromosomal changes such as deletion of 6q21, monoallelic...
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