Article
Origins of the malignant clone in typical Waldenstrom's macroglobulinemia.
Seminars in oncology - 1 Apr 2003
Sahota Surinder S, Forconi Francesco, Ottensmeier Christian H, Stevenson Freda K
Abstract excerpt
Histopathology and phenotypic considerations in IgM-secreting B-cell tumors allow distinction between different diseases, but insight into pathogenesis is restricted. Here, variable region (V) gene analysis can complement classification but, more importantly, can also reveal disease origins and clonal history. We used V(H) gene analysis to probe origins in Waldenstrom's macroglobulinemia (WM), and contrasted...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Immunoglobulin Class Switching
- Immunoglobulin Heavy Chains
- Immunoglobulin J-Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulin delta-Chains
- Mutation
- Phenotype
- Waldenstrom Macroglobulinemia