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Article

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jun 2008

Gray Michelle, Shirasaki Dyna I, Cepeda Carlos, André Véronique M, Wilburn Brian, Lu Xiao-Hong, Tao Jifang, Yamazaki Irene, Li Shi-Hua, Sun Yi E, Li Xiao-Jiang, Levine Michael S, Yang X William

Abstract excerpt

To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-mhtt with 97 glutamine repeats under the control of endogenous htt regulatory machinery on the BAC. BACHD mice exhibit progressive motor deficits, neuronal synaptic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18550760
DOI: 10.1523/JNEUROSCI.0857-08.2008
PMCID: PMC2630800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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