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Article

Calpain-dependent proteolysis of NF2 protein: involvement in schwannomas and meningiomas.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Sept 2000

Kimura Y, Saya H, Nakao M

Abstract excerpt

The neurofibromatosis type 2 (NF2) protein, known as merlin or schwannomin, is a tumor suppressor, and the NF2 gene has been found to be mutated in the majority of schwannomas and meningiomas, including both sporadically occurring and familial NF2 cases. Although the development of these tumors depends on the loss of merlin, the presence of tumors lacking detectable NF2 mutations suggests different mechanisms for...

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Identifiers

PMID: 11132929
DOI: 10.1046/j.1440-1789.2000.00326.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calpain-dependent proteolysis of NF2 protein: involvement in schwannomas and meningiomas.PMID 11132929Read ↗

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Missense mutations in the <i>NF2</i> gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic functionSemantic proximity Read ↗

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Schwannomas and Their PathogenesisSemantic proximity Read ↗

Molecular alterations in the neurofibromatosis type 2 gene and its protein rarely occurring in meningothelial meningiomas.Semantic proximity Read ↗

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