Neurofibromatosis 2: loss of merlin's protective spell.

doi:10.1016/s0959-437x(96)90016-7

Back to search

Article

Neurofibromatosis 2: loss of merlin's protective spell.

Current opinion in genetics & development - 1 Feb 1996

Gusella J F, Ramesh V, MacCollin M, Jacoby L B

Abstract excerpt

Schwannomas and meningiomas occur as multiple tumors in sufferers of neurofibromatosis 2 (NF2) and as solitary tumors in the general population due to the inactivation of a gene at chromosome 22q12. In 1993, a location cloning approach revealed this tumor suppressor, dubbed merlin, as a novel mem...

Topics

Animals
Genes, Neurofibromatosis 2
Humans
Membrane Proteins
Mutation
Neurofibromatosis 2
Neurofibromin 2

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.