Article
Molecular alterations in the neurofibromatosis type 2 gene and its protein rarely occurring in meningothelial meningiomas.
Journal of neurosurgery - 1 Jan 2001
Evans J J, Jeun S S, Lee J H, Harwalkar J A, Shoshan Y, Cowell J K, Golubic M
Abstract excerpt
OBJECT: The neurofibromatosis Type 2 (NF2) gene is the only tumor suppressor gene that has been clearly implicated in the development of benign meningiomas. Interestingly, previous data obtained by the authors indicate that reduced NF2 protein expression seldom occurs in meningothelial meningiomas, the most common histological type of meningioma. The goal of the current study was to explore further the hypothesis...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Calpain
- Enzyme Activation
- Female
- Genes, Tumor Suppressor
- Humans
- Male
- Membrane Proteins
- Meningeal Neoplasms
- Meningioma
- Middle Aged
- Mutation