Schwannomas and Their Pathogenesis

doi:10.1111/bpa.12125

Article

Schwannomas and Their Pathogenesis

23 Jan 2014

Abstract excerpt

Schwannomas may occur spontaneously, or in the context of a familial tumor syndrome such as neurofibromatosis type 2 (NF2), schwannomatosis and Carney's complex. Schwannomas have a variety of morphological appearances, but they behave as World Health Organization (WHO) grade I tumors, and only very rarely undergo malignant transformation. Central to the pathogenesis of these tumors is loss of function of merlin,...

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