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The Role of Merlin/NF2 Loss in Meningioma Biology

24 Oct 2019

Abstract excerpt

Mutations in the neurofibromin 2 (NF2) gene were among the first genetic alterations implicated in meningioma tumorigenesis, based on analysis of neurofibromatosis type 2 (NF2) patients who not only develop vestibular schwannomas but later have a high incidence of meningiomas. The NF2 gene product, merlin, is a tumor suppressor that is thought to link the actin cytoskeleton with plasma membrane proteins and...

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PMID: 31652973
DOI: 10.3390/cancers11111633

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