Article
dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila.
The International journal of developmental biology - 1 Oct 2000
Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias A M
Abstract excerpt
Members of the Tcf family of HMG box-containing transcriptional regulators mediate Wnt signalling in the nucleus. Current models suggest that in the absence of Wnt signalling, Tcf interacts with the repressor protein Groucho and suppresses the expression of Wnt targets. Wnt signalling leads to increases in the level of cytoplasmic beta catenin, which enters the nucleus, displaces Tcf from Groucho and leads to...
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