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Article

A method for detecting recent selection in the human genome from allele age estimates.

Genetics - 1 Sept 2003

Toomajian Christopher, Ajioka Richard S, Jorde Lynn B, Kushner James P, Kreitman Martin

Abstract excerpt

Mutations that have recently increased in frequency by positive natural selection are an important component of naturally occurring variation that affects fitness. To identify such variants, we developed a method to test for recent selection by estimating the age of an allele from the extent of haplotype sharing at linked sites. Neutral coalescent simulations are then used to determine the likelihood of this age...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14504236
DOI: 10.1093/genetics/165.1.287
PMCID: PMC1462736

Genes

HFE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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