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Article

Effect of stabilizing versus destabilizing interactions on plasminogen activator inhibitor-1.

Thrombosis and haemostasis - 1 Nov 2000

Vleugels N, Leys J, Knockaert I, Declerck P J

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is a unique member of the serpin family, as it spontaneously converts into a latent conformation. However, the exact mechanism of this conversion is not known. Previous studies reported that neutralizing monoclonal antibodies as well as reversal or removal of charges on the s3C-s4C turn results in a destabilization of PAI-1 leading to an accelerated conversion to its...

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PMID: 11127870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of stabilizing versus destabilizing interactions on plasminogen activator inhibitor-1.PMID 11127870Read ↗

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