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Article

The importance of helix F in plasminogen activator inhibitor-1.

Biochimica et biophysica acta - 3 Jan 2000

Vleugels N, Gils A, Bijnens A P, Knockaert I, Declerck P J

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is the only functionally labile serpin, as it converts spontaneously into a non-reactive 'latent' conformation. Several studies have suggested an important role for helix F in the functional behavior and stability of the serpins, especially for PAI-1. We constructed a mutant of PAI-1 (PAI-1-delhF) in which residues 127-158 (hF-thFs3A) were deleted. Whereas wild-type PAI-1...

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Identifiers

PMID: 10606763
DOI: 10.1016/s0167-4838(99)00224-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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