Article
Zinc-binding properties of Junín virus nucleocapsid protein.
The Journal of general virology - 1 Jan 2001
Tortorici M Alejandra, Ghiringhelli P Daniel, Lozano Mario E, Albariño César G, Romanowski Víctor
Abstract excerpt
The arenavirus nucleocapsid protein (N) is a highly basic 63 kDa protein with a dual function during the virus life-cycle. First, it is involved in essential steps of genome replication, promoting the synthesis of the full-length antigenomic copy of S RNA, and second it associates with the genomic RNA to form the nucleocapsid. We have expressed the N protein of Junín virus in E. coli and shown that it binds zinc...
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