Article
Mutational analysis of the Sendai virus V protein: importance of the conserved residues for Zn binding, virus pathogenesis, and efficient RNA editing.
Virology - 1 Aug 2002
Fukuhara Noriko, Huang Cheng, Kiyotani Katsuhiro, Yoshida Tetsuya, Sakaguchi Takemasa
Abstract excerpt
The V protein of Sendai virus (SeV) is nonessential for virus replication in cell culture but indispensable for viral pathogenicity in mice. At the C terminus of the V protein, there are amino acid residues conserved among the members of the Paramyxovinae subfamily that are clustered in three regions: region I, just downstream of the RNA editing site; and regions II and III, cysteine-rich zinc-finger-like...
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