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Identification of Two Functional Domains within the Arenavirus Nucleoprotein

16 Dec 2010

Abstract excerpt

Tacaribe virus (TCRV) belongs to the Arenaviridae family. Its bisegmented negative-stranded RNA genome encodes the nucleoprotein (N), the precursor of the envelope glycoproteins, the polymerase (L), and a RING finger matrix (Z) protein. The 570-amino-acid N protein binds to viral RNA, forming nucleocapsids, which are the template for transcription and replication by the viral polymerase. We have previously shown...

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PMID: 21159858
DOI: 10.1128/jvi.01875-10

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