Article
SF1 in the development of the adrenal gland and gonads.
Hormone research - 1 Jan 2003
Ozisik Gokhan, Achermann John C, Meeks Joshua J, Jameson J Larry
Abstract excerpt
SF1 (steroidogenic factor-1; NR5A1) is an orphan nuclear receptor that is expressed in the adrenal gland, gonads, spleen, ventromedial hypothalamus and pituitary gonadotroph cells. Combined approaches of targeted mutagenesis in mice and examination of the effects of naturally occurring mutations in humans have clarified the role of SF1 in steroidogenesis and development. Targeted disruption of SF1 (FTZF1) in mice...
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