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Article

Viral shedding and biodistribution of G207, a multimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in aotus.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2000

Todo T, Feigenbaum F, Rabkin S D, Lakeman F, Newsome J T, Johnson P A, Mitchell E, Belliveau D, Ostrove J M, Martuza R L

Abstract excerpt

G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that is currently in clinical trial for patients with malignant glioma. G207 exhibits an efficient oncolytic activity in tumor cells, yet minimal toxicity in normal tissue when injected into the brains of HSV-susceptible mice or nonhuman primates. In this study, we evaluated the shedding and biodistribution of clinical-grade...

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Identifiers

PMID: 11124059
DOI: 10.1006/mthe.2000.0200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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