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Article

Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.

Cancer research - 1 Nov 1995

Yazaki T, Manz H J, Rabkin S D, Martuza R L

Abstract excerpt

We have demonstrated that replication-competent attenuated mutants of herpes simplex virus type 1 (HSV-1) have therapeutic potential for malignant gliomas. Moreover, a recently described multiple mutant HSV (termed G207) has properties which may allow human clinical trials. G207 is able to replicate within and kill cells from three human malignant meningiomas in cell culture. In nude mice harboring s.c. human...

Topics

Animals
Female
Herpes Simplex
Herpesvirus 1, Human
Humans
Meningeal Neoplasms
Meningioma
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transplantation, Heterologous

Vaccines, Attenuated

Viral Vaccines

Source

Identifiers

PMID: 7585498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7585498-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.PMID 7585498Read ↗

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