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Article

Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice.

Journal of virology - 1 Apr 2000

Sundaresan P, Hunter W D, Martuza R L, Rabkin S D

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) mutants that are attenuated for neurovirulence are being used for the treatment of cancer. We have examined the safety of G207, a multimutated replication-competent HSV-1 vector, in mice. BALB/c mice inoculated intracerebrally or intracerebroventricularly with 10(7) PFU of G207 survived for over 20 weeks with no apparent symptoms of disease. In contrast, over 80% of animals...

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Source

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Identifiers

PMID: 10729157
DOI: 10.1128/jvi.74.8.3832-3841.2000
PMCID: PMC111891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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