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Article

Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates.

Journal of virology - 1 Aug 1999

Hunter W D, Martuza R L, Feigenbaum F, Todo T, Mineta T, Yazaki T, Toda M, Newsome J T, Platenberg R C, Manz H J, Rabkin S D

Abstract excerpt

This study examined the safety of intracerebral inoculation of G207, an attenuated, replication-competent herpes simplex virus type 1 (HSV-1) recombinant, in nonhuman primates. Sixteen New World owl monkeys (Aotus nancymae [karyotype 1, formerly believed to be A. trivirgatus]), known for their exquisite susceptibility to HSV-1 infection, were evaluated. Thirteen underwent intracerebral inoculation with G207 at...

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Identifiers

PMID: 10400723
DOI: 10.1128/JVI.73.8.6319-6326.1999
PMCID: PMC112710

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Source receipt: pubmed, retrieved 7 Sept 2026.

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